Francesco Paolo Ulloa Severino

This study identifies a cortical circuit involving ACC-D1+ neurons critical for initiating goal-directed movements and shows its therapeutic potential in Parkinsonian akinesia.

This study identifies Neurocan as an astrocyte-secreted protein that promotes inhibitory synapse formation and function through its C-terminal fragment.

This study shows that TSP1 and TSP2 from astrocytes are essential for synapse development and effort control during operant conditioning in mice.

The paper identifies a locus coeruleus-hippocampal dopamine pathway involved in operant reinforcement by showing D1+ dentate gyrus neurons mediate self-stimulation through optogenetic activation.

The paper introduces a new system for simultaneous calcium imaging and optogenetic stimulation in freely moving mice, demonstrating its ability to image and activate specific neurons and recreate behavior.

This study shows that training-induced excitatory synaptogenesis in the ACC->DMS circuit is required for effort control, not learning, and is mediated by the 2{delta}-1 protein.