Alex Cornean

The paper develops a cytosine base editing workflow to generate quality-controlled multiplex-knockout hiPSC lines for studying disease mechanisms.

This paper introduces ABE9-SpRY, an improved adenine base editor that generates precise point mutations in mouse embryos with high efficiency and reduced off-target effects.

The paper develops a base editing framework in medaka and zebrafish to functionally validate SNVs, demonstrating its application in recreating cardiac phenotypes and validating candidate genes for congenital heart disease.

The paper introduces hei-tag, a tag that enhances CRISPR/Cas9 and base editor efficiency across multiple species and applications.