Fred Winston

This study investigates how the histone chaperone Spt6 regulates the H3K36 methyltransferase Set2 by relieving its autoinhibition, impacting transcription and H3K36 methylation.

This paper shows that the Spt6 N-terminal domain binds histones and controls chromatin structure, with its function conserved between yeast and humans.

This study shows Spt6, a histone chaperone, is involved in DNA replication and genome stability in yeast, with mutations leading to replication stress and increased DNA damage.

The paper identifies suppressor mutations in yeast that allow survival without the essential transcription factor Spn1/Iws1 by revealing multiple pathways that compensate for its loss.

This study identifies Spt6's role in facilitating Abd1 recruitment to transcribed regions through its interaction with RNAPII and its impact on Abd1 levels.

This study identifies a network of histone chaperones and elongation factors that coordinate transcriptional accuracy and chromatin structure through their physical interactions.

This study shows that Spn1 is essential for normal mRNA levels, splicing of ribosomal protein transcripts, and histone modifications in yeast.

This study shows Spt6 represses transcription initiation at thousands of intragenic promoters and regulates initiation at most genic promoters, proposing a model of initiation-site competition.