Sara McArdle

This study integrates histopathological data from the human pancreas across T1D stages to identify novel histopathological correlates, particularly in the prodromal stage.

The paper quantifies early microglial structural changes in 5xFAD mice before amyloid plaques, revealing sex-specific differences and a link between morphology and phagolysosomal activity.

The paper quantifies macrophage infiltration in pancreatic tissue of type 1 diabetes donors and finds increased infiltration and HLA-II expression in islet regions, suggesting a role in disease progression.

The paper introduces a method to study cell-cell interactions at single-cell resolution, revealing unique transcriptomic signatures in T cell-monocyte complexes during TB and dengue infection.

PRESTO integrates large-scale -omics data and identifies disease-specific gene signatures through unsupervised dimensionality reduction and visualization.