Verena van der Heide

B cells sustain tumor-specific CD4 T cells to promote response to PD-1 targeted therapy

This study shows that B cells support tumor-specific CD4 T cells to enhance PD-1 blockade efficacy, but antibody secretion is not necessary for long-term survival.

Integrated histopathology of the human pancreas throughout stages of type 1 diabetes progression

This study integrates histopathological data from the human pancreas across T1D stages to identify novel histopathological correlates, particularly in the prodromal stage.

ICOS limits memory-like properties and function of exhausted PD-1+ CD8 T cells

This study shows ICOS limits the function of exhausted PD-1+ CD8 T cells by promoting their differentiation into less functional effector-like cells, and inhibiting ICOS improves anti-tumor responses.