Author

Carlos A. Aldrete

Stanford UniversityORCID 0000-0003-3795-4572Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 1 Research Focus:protein design· 1 Assay:protein sequence· 1 Assay:proteomics· 1

Frequent Co-Authors

Alexander E. VlahosiD· 2 shared Xiaojing J. GaoiD· 2 shared Connor C. CalliD· 1 shared Jeewoo KangiD· 1 shared Jimin PeiiD· 1 shared Lucas E. Sant’AnnaiD· 1 shared Lucy S. ChongiD· 1 shared Michael B. ElowitziD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersSynthetic Biology

Alexander E. VlahosORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Synthetic BiologyNature Chemical BiologyPeer-reviewedJan 15, 2025

Orthogonalized human protease control of secreted signals

Carlos A. Aldrete, Connor C. Call, Lucas E. Sant’Anna…·Xiaojing J. Gao

This paper develops hDIRECT, a platform using human-derived proteins to control cytokine activity in cell-based therapies, demonstrating orthogonalization through protease regulation.

13 citations

humanproteomics

𝕏 PostBluesky

Synthetic BiologyNature CommunicationsPeer-reviewedFeb 17, 2022

Protease-controlled secretion and display of intercellular signals

Alexander E. Vlahos, Jeewoo Kang, Carlos A. Aldrete…·Xiaojing J. Gao

This paper introduces a system called RELEASE that regulates protein secretion and surface display using protease-controlled mechanisms, enabling programmable intercellular communication for biomedical applications.

60 citationstop 5%

protein sequenceexperimental assay

𝕏 PostBluesky