Alexander E. Vlahos

An in planta single-cell screen to accelerate functional genetics

The paper introduces a single-cell screening platform called PIVOT for functional genetics in plants, demonstrating its ability to identify cytokinin signaling regulators.

Orthogonalized human protease control of secreted signals

This paper develops hDIRECT, a platform using human-derived proteins to control cytokine activity in cell-based therapies, demonstrating orthogonalization through protease regulation.

A complete suite for compact programming of protein secretion

The paper develops a modular protein secretion platform with tunable logic and control for synthetic biology applications in cell therapies.

Protease-controlled secretion and display of intercellular signals

This paper introduces a system called RELEASE that regulates protein secretion and surface display using protease-controlled mechanisms, enabling programmable intercellular communication for biomedical applications.