Author

Livia Spiga

Imperial College LondonORCID 0000-0003-3803-4321Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:protein sequence· 1

Frequent Co-Authors

John S. TregoningiD· 2 shared A. SchotsiD· 1 shared Charles Williams· 1 shared Daniel ReumanniD· 1 shared David J. PeeleriD· 1 shared Dinh Chuong NguyeniD· 1 shared Janis Schleusner· 1 shared Jorge Armero‐Gimenez· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersImmunology

John S. TregoningORCID

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2 papers

Recent·Most cited

ImmunologybioRxivPreprintSep 18, 2026

Spatiotemporal control of STING activation and saRNA delivery decouples humoral and cellular immunity

David J. Peeler, Ziyin Wang, Livia Spiga…·John S. Tregoning

This study shows that timing and location of STING activation relative to saRNA delivery affects humoral and cellular immune responses, with synchronized delivery enhancing T cell responses without impacting antibody production.

DOI 10.64898/2026.09.11.751026

experimental assaydrug response / drug discovery

𝕏 PostBluesky

Molecular BiologybioRxivPreprintAug 21, 2025

Le click c'est chic: a plug-and-play virus-like particle vaccination platform enabled by non-canonical amino acid incorporation and click chemistry in the tobacco BY-2 cell-free protein synthesis system

Jorge Armero‐Gimenez, Janis Schleusner, Ruud H. P. Wilbers…·Charles Williams

This paper introduces a method to incorporate non-canonical amino acids into proteins using the tobacco BY-2 cell-free system, enabling click chemistry for vaccine development.

DOI 10.1101/2025.08.21.671528

protein sequenceexperimental assay

𝕏 PostBluesky