Hajime Hirase

The paper introduces a mouse line for labeling blood and interstitial fluid with fluorescent proteins to study vascular structure and permeability in vivo.

This paper uses CRISPR/Cas9 to knock-in a fluorescent albumin gene in mice, enabling long-term visualization of cerebral circulation in both infant and adult mice.

This study investigates how locus coeruleus-norepinephrine system activity and astrocytic responses change during sleep states, revealing dynamic fluctuations in norepinephrine levels and their relationship to sleep processes.

The paper describes a two-photon photothrombosis protocol to induce depth-targeted single vessel thrombosis in rodent brains with high success rate.

This study shows that transient astrocytic Gq signaling enhances remote memory through adenosine A1 receptor-dependent mechanisms.

The paper investigates cortico-hippocampal network dynamics in mice, showing that postnatal environment modulates brain state-dependent activity patterns during SWR and theta oscillations.

The paper measures GABAergic synaptic transmission polarity during epileptogenesis in mouse CA3 hippocampus, finding a temporary reversal from inhibitory to excitatory during post-ictal periods.

This study confirms that AQP4 is essential for glymphatic fluid and solute transport in the rodent brain, as Aqp4 disruption reduces CSF influx and amyloid-beta efflux.