Ayumu Konno

This study shows that vagus nerve stimulation activates the default mode network, enhancing cognitive behaviors, while vagal-independent mechanisms affect the salience network.

This study establishes a SCA34 mouse model with early glial activation and cerebellar neuron degeneration, linking microglial activation to motor dysfunction and neurodegeneration.

This paper develops a compact promoter for AAV gene therapy targeting inhibitory neurons, showing efficacy in treating epilepsy by restoring GABA function.

The paper evaluates BBB-penetrant AAV capsids in marmosets over a decade and identifies VCAP-102 as a superior candidate for systemic gene therapy.

The paper introduces a mouse line for labeling blood and interstitial fluid with fluorescent proteins to study vascular structure and permeability in vivo.

This paper develops an AAV vector system with optimized miR.Ts placement to achieve specific and efficient transgene expression in microglia.

The paper evaluates AAV capsid/promoter combinations for cell type-specific gene expression in marmoset cerebral cortex, identifying optimal pairs for neurons, astrocytes, and oligodendrocytes.

This paper uses CRISPR/Cas9 to knock-in a fluorescent albumin gene in mice, enabling long-term visualization of cerebral circulation in both infant and adult mice.

The paper develops a Cre-free method to monitor oxytocin neuron activity in lactating mice and shows that pulsatile activity depends on mother-pup contact.

The paper identifies oxytocin neurons as key regulators of paternal caregiving in male mice and shows enhanced excitatory connections from lateral hypothalamus neurons in fathers.

The paper identifies a specific PPC cell ensemble that mediates memory updating by interacting with the anterior cingulate cortex during retrieval.

This study shows that deletion of class II ARF causes essential tremors by impairing Nav1.6 trafficking to Purkinje cell axon initial segments.