Discovery of Tankyrase scaffolding inhibitor specifically targeting the ARC4 peptide binding domain
Chiara Bosetti, Albert Galera‐Prat, Sven T. Sowa, Alexandra Gade, Cláudia Braga, Shoshy Alam Brinch, Faranak Nami, Johan Pääkkönen, Veeti Pulju, Maureen Tania Meling, María Candamo-Lourido, Jo Waaler, Mads H. Clausen, L. Lehtiö
The paper identifies a Tankyrase scaffolding inhibitor, S8 (ARCher-142), that selectively targets the ARC4 peptide binding domain with 8 µM potency.
Structure · Jan 30, 2026Peer-reviewedBiochemistry