Kosuke Yamaguchi

The paper shows DNA methylation is largely maintained during UV damage repair through recruitment of DNMT1 and DNMT3A, driven by UHRF1 and repair endonucleases, and linked to histone dynamics and transcriptional response.

The paper shows that reduced DNA methylation in cancer cells leads to senescence without DNA damage, involving p21 and cGAS, and demonstrates this in vivo.

This study shows UHRF1 has non-canonical roles beyond DNMT1 activation in maintaining DNA methylation homeostasis in cancer cells.

The paper identifies new regulators of germline genes and 2-cell like cell state through a genome-wide CRISPR knock-out screen in mouse ES cells.

This study shows that DOT1L regulates chromatin reorganization and gene expression in male germ cells, leading to fertility defects in its absence.