DNA methylation protects cancer cells against senescence
Xiaoying Chen, Kosuke Yamaguchi, Brianna Rodgers, Delphine Goehrig, David Vindrieux, Xavier Lahaye, Matthieu Nolot, Laure Ferry, Sophie Lanciano, Nadine Martin, Pierre R. Dubus, Fumihito Miura, Takashi Ito, Gaël Cristofari, Nicolas Manel, , Pierre‐Antoine Defossez
The paper shows that reduced DNA methylation in cancer cells leads to senescence without DNA damage, involving p21 and cGAS, and demonstrates this in vivo.
Nature Communications · Jul 1, 2025Peer-reviewedMolecular Biology