Hao Chen

Instant fluorescence lifetime imaging microscopy reveals mechano-metabolic reprogramming of stromal cells in breast cancer peritumoral microenvironments

This study uses instant FLIM to show that mechanical compression of stromal cells in breast cancer models alters their metabolism, with distinct effects on fibroblasts and adipocytes, validated by transcriptomics and mitochondrial analysis.

Complex regulatory interactions at GDF5 shape joint morphology and osteoarthritis disease risk

The paper investigates regulatory interactions at the GDF5 locus, showing that epistasis between variants, rather than individual variants, influences disease risk and joint morphology.