Author

Chrysovalantou E. Xirouchaki

Monash UniversityORCID 0000-0002-8153-8958Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:imaging· 1 Assay:metabolomics· 1

Frequent Co-Authors

Andrew PhilpiD· 1 shared Anne BigotiD· 1 shared Christina Anne MitchelliD· 1 shared Eamon CoughlaniD· 1 shared Esther García-DomíngueziD· 1 shared Florian WiedeiD· 1 shared Junichi SadoshimaiD· 1 shared Marcus MobergiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperPhysiology

Andrew PhilpORCID

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1 paper

Recent·Most cited

A decline in skeletal muscle NOX4 abrogates adaptive homeostasis and exacerbates ageing

Chrysovalantou E. Xirouchaki, Esther García-Domínguez, Eamon Coughlan, Meagan J. McGrath, Saveen Giri, Shuwei Liang, Florian Wiede, Anne Bigot, Junichi Sadoshima, Mari Carmen Gómez‐Cabrera, Andrew Philp, Marcus Moberg, William Apró, William Roman, Christina Anne Mitchell, Tony Tiganis

This study shows that declining NOX4 in skeletal muscle with age disrupts NFE2L2 adaptive homeostasis, leading to muscle dysfunction and systemic aging, which can be mitigated by sulforaphane or exercise.

Science Advances · Jun 10, 2026Peer-reviewedPhysiology