Tony Tiganis

A decline in skeletal muscle NOX4 abrogates adaptive homeostasis and exacerbates ageing

This study shows that declining NOX4 in skeletal muscle with age disrupts NFE2L2 adaptive homeostasis, leading to muscle dysfunction and systemic aging, which can be mitigated by sulforaphane or exercise.

Discrete cytokine signaling networks instruct distinctsynovial pathotypes in inflammatory arthritis

The paper identifies distinct cytokine signaling networks in mouse models of arthritis that mirror human RA synovial pathotypes, revealing molecular mechanisms underlying disease heterogeneity.

Stepwise progression of beta-selection during T cell development as revealed by histone deacetylation inhibition

This study uses histone deacetylase inhibition to reveal a new stage in T cell β-selection, showing how CD28, CD5, Lef1, and CD2 coordinate to regulate the checkpoint.

Torso-like is a component of the hemolymph and regulates the insulin signalling pathway in Drosophila

The paper identifies Torso-like as a secreted protein that regulates insulin signalling in Drosophila by modulating insulin-like peptide activity and developmental timing.