Thomas D. Grant

Ultrafast X-Rays Capture Retinal Traversing Conical Intersection in Rhodopsin

This study uses ultrafast X-ray scattering to observe retinal cis-trans isomerization in rhodopsin, revealing how cofactor dynamics drive activation without crystal lattice constraints.

Structure of a Stand-Alone Homodimeric NRPS Condensation Domain Reveals Occlusion of the Canonical Carrier-Protein Interface

This study determines the structure of OaaC, a condensation domain involved in fatty acid amide biosynthesis, revealing how it occludes the ACP-binding site and is regulated by substrate-dependent oligomerization.

Minimized Sample Consumption for Time-Resolved Serial Crystallography Applied to the Redox Cycle of Human NQO1

This paper demonstrates a method to reduce sample consumption in time-resolved serial crystallography by using segmented droplet generation and mix-and-inject approaches for studying NQO1's redox cycle.

Structure Characterization of Bacterial Microcompartment Shells via X-ray Scattering and Coordinate Modeling: Evidence for adventitious capture of cytoplasmic proteins

The paper uses SAXS and PDDF to analyze BMC shell structures and enzyme encapsulation in Haliangium ochraceum BMCs expressed in E. coli, showing cytoplasmic protein capture during assembly.