Zeyang Shen

This study identifies distinct skin microbiome features associated with atopic phenotypes in infancy, including AD, FS, and FA, and their interactions with host genetics.

This study identifies metabolic pathways and genes critical for Candida auris growth in skin-like conditions, showing their role in nutrient utilization and potential as targets for controlling colonization.

The paper presents a genome catalog of the early-life human skin microbiome, expanding diversity and improving classification rates using metagenomic data from infants and their mothers.

The paper systematically analyzes naturally occurring insertions and deletions (InDels) to assess their impact on transcription factor spacing and identifies tolerant and sensitive TF pairs.

The paper identifies how non-coding genetic variation affects macrophage responses to IL-4 by analyzing SNP and InDel effects across five inbred mouse strains.

MAGGIE identifies DNA sequence motifs mediating TF binding and function by linking genetic variation to epigenomic changes, improving sensitivity and specificity over existing methods.

The paper identifies cell type-specific enhancer-promoter connectivity in the human brain and links these to disease risk variants in Alzheimer's and psychiatric disorders.

The paper identifies non-redundant DNA binding activities of AP-1 family members in macrophages using ChIP-sequencing and machine learning, showing motif ensembles drive factor-specific binding.