Marten A. Hoeksema

This study identifies an EZH2/TRIM28 epigenetic axis that regulates heparan sulfate remodeling and promotes melanoma metastasis.

The paper identifies an unconventional JAK1/2-STAT3 signaling pathway in macrophage IFNγ responses, showing STAT3 activation and heterodimerization with STAT1, but limited gene regulatory contribution.

This study shows EPA induces an anti-inflammatory transcriptomic profile in CD4+ T cells, independent of triglyceride lowering, potentially explaining its cardiovascular benefits.

This study shows that oleic acid pre-exposure rewires CD4+ T cell metabolism, promoting pro-inflammatory differentiation upon activation.

The paper evaluates brain somatic mosaicism in the adult human to identify rules governing cellular distribution during embryogenesis.

The paper systematically analyzes naturally occurring insertions and deletions (InDels) to assess their impact on transcription factor spacing and identifies tolerant and sensitive TF pairs.

The paper identifies how non-coding genetic variation affects macrophage responses to IL-4 by analyzing SNP and InDel effects across five inbred mouse strains.

MAGGIE identifies DNA sequence motifs mediating TF binding and function by linking genetic variation to epigenomic changes, improving sensitivity and specificity over existing methods.