Richard Saffery

Skin microbiome composition and function in the development of atopic diseases during infancy

This study identifies distinct skin microbiome features associated with atopic phenotypes in infancy, including AD, FS, and FA, and their interactions with host genetics.

Genetic, intrinsic, and environmental determinants of innate immune cytokine responses in healthy four-year-old children

This study identifies genetic, intrinsic, and environmental factors influencing innate immune cytokine responses in four-year-old children, finding strong genetic and inflammatory biomarker associations.

Prenatal Environmental Determinants of Aromatase Brain-Promoter Methylation in Cord Blood: Chemical, Airborne, Pharmacological, and Nutritional Factors

The paper examines prenatal environmental factors affecting CYP19A1 promoter methylation in cord blood using WQS regression, finding associations with bisphenols, sunlight, mould, phthalates, folate, and air pollution.

Prenatal DEHP plastic chemical exposure increases the likelihood of child autism and ADHD symptoms through epigenetic programming

This study shows prenatal DEHP exposure increases ASD and ADHD symptoms through DNA methylation changes in children.

Genome-wide analyses of vocabulary size in infancy and toddlerhood: associations with Attention-Deficit/Hyperactivity Disorder and cognition-related traits

This study identifies genetic links between early vocabulary development and ADHD and cognition traits using genome-wide analyses.

A genome catalog of the early-life human skin microbiome

The paper presents a genome catalog of the early-life human skin microbiome, expanding diversity and improving classification rates using metagenomic data from infants and their mothers.

The X-factor in ART: does the use of Assisted Reproductive Technologies influence DNA methylation on the X chromosome?

This study investigates DNA methylation differences on the X chromosome in ART-conceived versus naturally-conceived newborns, finding sex-specific methylation changes linked to neurodevelopmental processes.

Gender Affirming Hormone Therapy induces specific DNA methylation changes in blood

This study identifies DNA methylation changes in blood of transgender individuals undergoing gender affirming hormone therapy, showing most changes are progressive and not related to early-established sex-specific patterns.

Developmental and Intergenerational Landscape of Human Circulatory Lipidome and its Association with Obesity Risk

The paper maps the developmental and intergenerational changes in the human circulatory lipidome and identifies lipid signatures associated with obesity risk in mothers and offspring.

Causes of variation in epigenetic aging across the lifespan

This study investigates the causes of variation in DNA methylation age across the lifespan, finding that environmental factors, particularly shared ones, are the main drivers.

Characteristics of DNA methylation and gene expression in regulatory features on the Infinium 450k Beadchip

The paper examines the relationship between DNA methylation and gene expression in primary T-lymphocytes, finding that promoter methylation correlates with expression but gene body methylation does not, with variations by CpG density and genomic context.