BiochemistrybioRxivPreprint
A long-chain heparan sulfate capture mechanism directs paracrine GDNF-GFRα1 signalling through RET
Mia I. Zol-Hanlon, Beatrice Rix, Salomé Bodet-Lefèvre…·Neil Q. McDonald
The paper reveals how long-chain heparan sulfate (HS) facilitates paracrine GDNF-GFRα1 signaling by forming a multi-protein complex with RET, essential for signaling in trans but not in cis.
DOI 10.64898/2026.05.20.726209