Benjamin Schumann

An in vivo chemical genetic approach for targeted glycoproteome analysis in Drosophila melanogaster

This paper introduces FlyMOE, a chemical-genetic platform for targeted glycoproteome analysis in Drosophila, using mass spectrometry to study glycosylation in vivo.

Mutations in severe human H5N1 cases facilitate evasion from human mucus and antivirals

This study examines mutations in H5N1 influenza virus HA that affect receptor binding and antiviral susceptibility, finding reduced sialic acid binding correlates with mucus evasion and antiviral resistance.

Iterative Bump-and-hole engineering creates a bioorthogonal reporter for N-acetylglucosaminyltransferase I

The paper develops a bioorthogonal reporter for MGAT1 by iteratively engineering a UDP-GlcNAc analog with a chemical tag, enabling specific substrate incorporation in mammalian cells.

A long-chain heparan sulfate capture mechanism directs paracrine GDNF-GFRα1 signalling through RET

The paper reveals how long-chain heparan sulfate (HS) facilitates paracrine GDNF-GFRα1 signaling by forming a multi-protein complex with RET, essential for signaling in trans but not in cis.

Siglec-engaging immunosuppressive sialoglycans are upregulated in prostate cancer and are targetable to suppress bone metastasis

This study identifies Siglec-engaging sialoglycans as upregulated in prostate cancer and shows they can be targeted to suppress bone metastasis using a bisialidase.

Cell-specific Bioorthogonal Tagging of Glycoproteins

The paper introduces BOCTAG, a method to label glycoproteins in specific cell types within mixed cultures, enabling analysis of cell-specific glycosylation.

Metabolic precision labeling enables selective probing of O-linked N-acetylgalactosamine glycosylation

This paper introduces GalNAzMe, a monosaccharide probe that selectively labels O-GalNAc glycosylation in living cells, enabling detailed study of this cancer-relevant modification.

Chemical precision glyco-mutagenesis by glycosyltransferase engineering in living cells

The paper introduces a method to chemically tag glycans in living cells using engineered glycosyltransferases to study glycan structure and biosynthesis.