NeurosciencebioRxivPreprint
Dysregulated Proline Metabolism Contributes to Subretinal Fibrosis in Neovascular AMD: Therapeutic Potential of Prolyl-4-Hydroxylase Inhibition
Yue Zeng, Ting Zhang, Elisa Eleanor Cornish…·Mark C. Gillies
This study identifies proline metabolism, specifically proline hydroxylation via P4HA1, as a driver of subretinal fibrosis in nAMD and shows that P4HA1 inhibition reduces fibrosis in mouse models.