Katherine Ridley

Typical development of synaptic and neuronal properties can proceed without microglia in the cortex and thalamus

This study shows that neurodevelopmental processes in the cortex and thalamus can occur normally without microglia, using a genetically modified mouse model.

Microglia determine beta-amyloid plaque burden but are non-essential for downstream pathology

This study shows microglia promote beta-amyloid plaque formation but are not required for subsequent pathological changes in Alzheimer's disease.

Single-cell atlas of human liver development reveals pathways directing hepatic cell fates

This study creates a single-cell atlas of human liver development, identifying pathways and factors that guide hepatic cell fates and improving hepatocyte-like cell functionality.

Time-resolved single-cell RNAseq profiling identifies a novel Fabp5-expressing subpopulation of inflammatory myeloid cells in chronic spinal cord injury

Nutritional signals rapidly activate oligodendrocyte differentiation in the adult hypothalamic median eminence

The paper shows that refeeding after fasting rapidly activates oligodendrocyte differentiation in the hypothalamic median eminence, altering extracellular matrix proteins and using mTORC1 signaling to monitor nutritional signals.