The paper identifies transmembrane protein 97 as a synaptic receptor for amyloid beta in human Alzheimer's disease using advanced microscopy and drug intervention studies.

Acta Neuropathologica · Feb 6, 2024Peer-reviewedNeuroscience

Reducing voltage-dependent potassium channel Kv3.4 levels ameliorates synapse loss in a mouse model of Alzheimers disease

Jie Yeap, Chaitra Sathyaprakash, Jamie Toombs, Jane Tulloch, Cristina Scutariu, Jamie L. Rose, Karen Burr, Caitlin Davies, Martí Colom‐Cadena, Siddharthan Chandran, Charles H. Large, Matthew JM Rowan, Martin J. Gunthorpe, Tara L. Spires‐Jones

This study shows reducing Kv3.4 levels in a mouse model of Alzheimer's disease reduces synapse loss and changes in spine morphology.

Brain and Neuroscience Advances · Jan 1, 2022Peer-reviewedNeuroscience

Comparative profiling of the synaptic proteome from Alzheimer’s disease patients with focus on the APOE genotype

Raphael Hesse, Maica Llavero Hurtado, Rosemary J. Jackson, Samantha L. Eaton, Abigail G. Herrmann, Martí Colom‐Cadena, Makis Tzioras, Declan King, Jamie L. Rose, Jane Tulloch, Chris-Anne McKenzie, Colin Smith, Christopher M. Henstridge, Douglas J. Lamont, Thomas M. Wishart, Tara L. Spires‐Jones

The paper identifies over 5,500 synaptic proteins in Alzheimer’s disease and controls, revealing APOE4-associated changes in synaptic and mitochondrial function and neuroimmune signaling.

Acta Neuropathologica Communications · Dec 1, 2019Peer-reviewedNeuroscience