Katharine Compton Abruzzi

This paper benchmarks circadian detection methods on single-cell RNAseq data and proposes a subsampling and harmonic regression strategy for detecting circadian genes.

The paper identifies novel clock neuron subtypes in Drosophila that regulate sleep timing through distinct projection patterns and a common receptor.

The paper compares TRIBE and STAMP methods for identifying RNA binding protein targets in human and Drosophila cells, finding TRIBE more effective in Drosophila.

The paper identifies heterogeneous clock and dopaminergic cell types in Drosophila using single-cell sequencing and shows connectivity molecules best characterize these neuron groups.

The paper identifies dopamine and GPCR-mediated modulation in Drosophila clock neurons that regulate sleep timing.

The paper introduces RiboTRIBE, a method to monitor translation by fusing ADAR to ribosomal proteins, and finds that editing occurs preferentially on polyribosome-associated transcripts.

The paper characterizes Drosophila circadian neurons using single-cell RNA sequencing, identifying 17 cell categories with time-dependent gene expression patterns.

The paper identifies a novel AstC/AstC-R2 signaling pathway in Drosophila that modulates evening locomotor activity under short photoperiods.