Author

James A. Ankrum

University of IowaORCID 0000-0003-3959-6158Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Assay:metabolomics· 1

Frequent Co-Authors

Samuel B. StephensiD· 2 shared Siming LiuiD· 2 shared Yumi ImaiiD· 2 shared Aditya Joglekar· 1 shared Aidan Freshly· 1 shared Akansha Mishra· 1 shared Anamika Vikram· 1 shared Andrew S. GreenbergiD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersCell Biology

Samuel B. StephensORCID

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3 papers

Recent·Most cited

Cell BiologybioRxivPreprintJan 29, 2025

Proinflammatory cytokines mediate pancreatic beta-cell specific alterations to Golgi morphology via iNOS-dependent mitochondrial inhibition

Sandra E. Blom, Riley M. Behan-Bush, James A. Ankrum…·Samuel B. Stephens

This study shows proinflammatory cytokines alter pancreatic beta-cell Golgi structure via iNOS-dependent mitochondrial inhibition, contributing to secretory dysfunction in T1D.

1 citation

humanexperimental assay

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Molecular BiologybioRxivPreprintNov 17, 2024

Lipid droplet protein Perilipin 2 is critical for the regulation of insulin secretion through beta cell lipophagy and glucagon expression in pancreatic islets

Siming Liu, Israel J Wipf, Aditya Joglekar…·Yumi Imai

This study shows that PLIN2 regulates lipophagy in beta cells to prevent fatty acid accumulation in mitochondria, which impairs insulin secretion and mitochondrial function.

1 citation

humanexperimental assay

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Molecular BiologyJCI InsightPeer-reviewedMar 30, 2021

Perilipin2 down-regulation in beta cells impairs insulin secretion under nutritional stress and damages mitochondria

Akansha Mishra, Siming Liu, Joseph A. Promes…·Yumi Imai

This study shows that reducing Perilipin2 in beta cells impairs insulin secretion and mitochondrial function under nutritional stress.

29 citations

mousehuman

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