Stephen M Gottschalk

The paper analyzes single-cell RNA sequencing data from pediatric B-ALL and AML patients to identify distinct T-cell subsets and their associations with clinical outcomes.

This paper demonstrates that bioPROTACs can reprogram CAR T-cells by targeting DNMT3A, offering a tunable alternative to gene editing for enhancing T-cell function.

This study shows that deleting Regnase-1 in CAR T cells enhances their antitumor activity against osteosarcoma by creating a proinflammatory tumor microenvironment.