Anthony A. High

This paper develops an AI framework to interpret single-cell RNA-seq data from pediatric solid tumors, identifying tumor-specific surface antigen pairs for targeted therapies.

This study identifies tissue-specific proteomic changes in a Drosophila SCA17 model, showing polyglutamine-expanded TBP affects pathways beyond transcription.

This study evaluates false discovery rate and statistical power in DIA proteomics using technical replicates and spike-in experiments, revealing discrepancies between nominal and true FDR and showing power dependence on fold change and abundance.

JUMPlion improves DIA proteomics by recovering missing ion-level values, enhancing protein quantification accuracy in low-input and single-cell analyses.

This study identifies APOE as a presynaptic protein enriched in aged female mice, showing it modulates neurotransmitter release and affects synaptic function.

This paper demonstrates that bioPROTACs can reprogram CAR T-cells by targeting DNMT3A, offering a tunable alternative to gene editing for enhancing T-cell function.

The paper presents a cell type-resolved proteomic atlas of Alzheimer's disease mouse models, identifying thousands of cell-specific protein changes and highlighting astrocyte-microglia signaling.

The paper quantifies the proteomic composition of amyloid plaques in AD models and human brains, revealing stage-dependent remodeling and conserved proteins across species.

The paper identifies glycerophospholipid biosynthesis upregulation as a mechanism of chemoresistance in SLFN11-loss Ewing sarcoma and shows that inhibiting this pathway enhances DNA-damaging agent efficacy.

This study shows that midkine reduces Aβ fibril formation and amyloid plaque development in Alzheimer's disease models.