Hao Shi

This study identifies MOZ and HBO1 as molecular dependencies in NUP98-rearranged AML, showing their inhibition reduces leukemic burden and synergizes with Menin inhibitors.

This study shows that deleting Regnase-1 in CAR T cells enhances their antitumor activity against osteosarcoma by creating a proinflammatory tumor microenvironment.

The paper introduces HiPR-Map, a spectral imaging technology for high-phylogenetic-resolution spatial mapping of microbial communities, and applies it to analyze an LBP in the murine gut.

Perturb-DBiT co-sequences spatial transcriptomes and gRNAs on one tissue section, supporting genome-wide in vivo CRISPR screens in FFPE and fresh-frozen tumors across three cancer models.

scMINER identifies hidden drivers and network rewiring in single-cell RNA-seq data using mutual information, outperforming existing methods in clustering and network inference.

The paper identifies TCF4 and ID3 as key transcription factors driving mammary epithelial stem cell differentiation through single-cell RNA sequencing analysis.