Glenn L. Radice

Vinculin Y822 phosphorylation regulates cardiomyocyte adhesion dynamics and adherens junction maturation in the heart

This study shows that vinculin Y822 phosphorylation regulates cardiomyocyte adhesion dynamics and adherens junction maturation, with loss of function leading to cardiac dysfunction later in life.

Abl kinases regulate FGF signaling independent of Crk phosphorylation to prevent Peters anomaly

This study identifies Abl kinases as regulators of FGF signaling that prevent Peters anomaly by modulating RhoA and Rac1 activity through the Ptpn12-p130Cas pathway.

Actomyosin-mediated cellular tension promotes Yap nuclear translocation and myocardial proliferation through alpha5 integrin signaling

This study shows that actomyosin contractility promotes cardiomyocyte proliferation by increasing Yap nuclear translocation via alpha5 integrin signaling in the postnatal heart.