Mathieu Letellier

This paper introduces an in vitro model of embryonic mouse hindbrain explants that enables longitudinal, multimodal analysis of olivo-cerebellar circuit development at single-cell resolution.

This study develops a tagged knock-in mouse strain to visualize and isolate endogenous neuroligin-1, revealing its presence at both excitatory and inhibitory synapses.

The paper shows MDGAs delay excitatory synapse development by altering neuroligin behavior through fast diffusion and reduced mobility.

The paper identifies synaptopodin as a synaptic tag regulated by miR124 that enables non-uniform and input-specific homeostatic synaptic plasticity in response to activity deprivation.

This study uses optogenetics to show that phosphorylation of neuroligin-1 promotes excitatory synaptic differentiation and potentiation.

The paper shows that neuroligin-1 alignment with AMPA receptor nanodomains is critical for synaptic transmission efficiency, as disrupting this alignment reduces transmission.