Vanessa Leone

This study shows that dietary cholesterol and saturated fat together drive fibrosing MASH via gut microbiota changes, specifically increasing Parasutterella spp. and activating hepatic stellate cells.

The paper shows that sample collection time significantly affects microbiome study conclusions, more than experimental interventions or dietary changes.

This paper identifies peptide YY (PYY) as a novel antimicrobial peptide produced by Paneth cells with selective antifungal activity against Candida albicans hyphae, maintaining gut fungal commensalism.