Tobias Friedrich

The paper shows lineage-determining transcription factors position enhancers and promoters to enable multi-enhancer regulation of oncogenes in lymphoma and T-cell leukemia.

The paper investigates RBPJ-DNA binding kinetics and cofactor interactions, finding that kinetic stability, not thermodynamic, governs target site specificity and that mutations affect both association and dissociation rates.

This study identifies ZNF512B as a repressor of gene expression that interacts with the NuRD complex via a conserved motif and can cause chromatin aggregation independently of NuRD.

The paper identifies genomic features associated with Notch responsiveness by analyzing RBPJ binding dynamics and develops a machine learning approach to predict Notch responsiveness in different cellular contexts.

This study identifies HMG20A as a key regulator of head and heart development by modulating transcription programs in neural crest cells and cardiomyocytes through its association with the H2A.Z/PWWP2A/NuRD complex.