Pedro A. Piedra

Streptococcus pneumoniae colonization modulates human nasal epithelial responses to respiratory syncytial virus infection

This study shows that Streptococcus pneumoniae precolonization reduces RSV levels and modulates epithelial transcriptional responses to RSV infection more than other nasal bacteria.

Evolutionary dynamics of Respiratory Syncytial Virus in pre-pandemic, pandemic, and post-pandemic periods in Houston, Texas, USA

This study analyzes RSV evolutionary dynamics across pre-pandemic, pandemic, and post-pandemic periods in Houston, finding reduced diversity during the pandemic and increased non-synonymous mutations in RSV/B.

Oral dosing of the nucleoside analog obeldesivir is efficacious against RSV infection in African green monkeys

This study shows that oral obeldesivir is effective against RSV infection in African green monkeys, reducing viral load significantly.

Complete Genomic Characterization of Global Pathogens, Respiratory Syncytial Virus (RSV), and Human Norovirus (HuNoV) Using Probe-based Capture Enrichment.

This paper presents a probe-based capture enrichment method to obtain full-length genomes of RSV and HuNoV from clinical samples, achieving high completeness and improving variant tracking.

Pediatric human nose organoids demonstrate greater susceptibility, epithelial responses, and cytotoxicity than adults during RSV infection.

This study compares RSV infection responses in pediatric and adult nose organoids, finding pediatric organoids show greater susceptibility, cytokine response, and cellular damage.

Examining intra-host genetic variation of RSV by short read high-throughput sequencing

The paper analyzes intra-host RSV genetic variation using short-read sequencing, finding low variation but differences between genomic and transcriptomic data.

Oligonucleotide Capture Sequencing of the SARS-CoV-2 Genome and Subgenomic Fragments from COVID-19 Individuals

This study develops an oligonucleotide capture sequencing method to generate SARS-CoV-2 genomic and transcriptome sequences from clinical samples, revealing differential transcriptional activity and ORF10 expression.

Genotype-dependent and non-gradient patterns of RSV gene expression

This study shows RSV gene expression is genotype-dependent and non-gradient, with the G gene consistently more expressed than upstream genes, suggesting a novel transcriptional regulation mechanism involving GS signal N-phase alignment.