Kanza M. Khan

This study shows that adolescent social isolation promotes tau spread in raphe nuclei, causing depression-like and pain-related symptoms in Alzheimer's disease.

The paper identifies tau pathology in the dorsal raphe nucleus as a potential early indicator of Alzheimer's disease, linked to behavioral changes and neuroinflammation.

This study identifies the lateral septum as a key circuit involved in ketamine-induced social deficits, showing that its hypoactivation contributes to schizophrenia-like behaviors.

This paper shows that adolescent isolation in mice leads to type 2 diabetes and identifies a serotonin/GLP-1 neural circuit as a potential target for understanding the link between social isolation and diabetes.

This study shows chronic alcohol exposure increases social avoidance in male mice by enhancing serotonergic inputs to the nucleus accumbens, which inhibits dopamine release and reduces social motivation.

This study shows that adolescent ethanol exposure in mice leads to long-term pain sensitivity, neuroinflammation, and serotonergic deficits, with microglial activation in the dorsal raphe nucleus as a key driver.