Author

Kimberly L. Fiock

University of IowaORCID 0000-0002-5376-1589Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 5 Research Focus:cell type annotation· 3 Assay:bulk RNA-seq· 2 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Assay:imaging· 2 Organism:mouse· 2

Frequent Co-Authors

Marco M. HeftiiD· 4 shared Ryan K. BettersiD· 2 shared Amy C. GottschalkiD· 1 shared Ann Carolyn McKeeiD· 1 shared Ann-Shyn Chiang· 1 shared Benjamin J. CooperiD· 1 shared Bertrand R. HuberiD· 1 shared Bi‐Chang CheniD· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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4 shared papersNeuroscience

Marco M. HeftiORCID

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5 papers

Recent·Most cited

Physicochemical balancing facilitates fast cyclic immunolabeling in centimeter-scale FFPE tissues

Ya‐Hui Lin, Chao-Yin Huang, Yin-Hsu Chen, Yen‐Hui Chen, Ping‐Liang Ko, Heng‐Hua Hsu, Yi‐Chung Tung, Yu-Fang Chen, Yu-Fang Chen, Ann-Shyn Chiang, Chih‐Ming Ho, Da-Jeng Yao, Kimberly L. Fiock, Kuo-Chuan Wang, Chin-Hsien Lin, , Li‐An Chu

The paper introduces FIDELITY, a method for rapid cyclic immunolabeling of FFPE tissues, enabling multi-cycle protein profiling in intact specimens.

bioRxiv · Sep 17, 2026 · PreprintNeuroscience

Tau pathology in the dorsal raphe may be a prodromal indicator of Alzheimer's disease

Samantha R. Pierson, Kimberly L. Fiock, Ruixiang Wang, Nagalakshmi Balasubramanian, Jessica Reinhardt, Kanza M. Khan, Thomas D. James, Mikayla L Hunter, Benjamin J. Cooper, Hannah R. Williamsen, Ryan K. Betters, Kaancan Deniz, Gloria S. Lee, Georgina M. Aldridge, Marco M. Hefti, Catherine Anne Marcinkiewcz

The paper identifies tau pathology in the dorsal raphe nucleus as a potential early indicator of Alzheimer's disease, linked to behavioral changes and neuroinflammation.

Molecular Psychiatry · Aug 14, 2024Peer-reviewedNeuroscience

Repetitive head impacts induce neuronal loss and neuroinflammation in young athletes

Morgane L M D Butler, Nida Pervaiz, Kerry Breen, Samantha M. Calderazzo, Petra Ypsilantis, Yichen Wang, Julia Cammasola Breda, Sarah A. Mazzilli, Raymond Nicks, Elizabeth Spurlock, Marco M. Hefti, Kimberly L. Fiock, Bertrand R. Huber, Victor E. Alvarez, Thor D. Stein, , Jonathan D. Cherry

This study shows that repetitive head impacts in young athletes cause neuronal loss and neuroinflammation before CTE pathology, with specific cellular changes linked to disease progression.

bioRxiv · Mar 26, 2024 · PreprintNeuroscience

Determinants of Astrocytic Pathology in Stem Cell Models of Primary Tauopathies

Kimberly L. Fiock, Jordan N. Hook, Marco M. Hefti

The paper investigates the origins of astrocytic tau aggregates in tauopathies and finds that astrocytes preferentially uptake neuronal 4R tau, which is impaired by inflammation and nutritional stress.

Acta Neuropathologica Communications · Oct 6, 2023Peer-reviewedNeuroscience

Characterization of the Tau Interactome in Human Brain Reveals Isoform-Dependent Interaction with 14-3-3 Family Proteins

Ryan K. Betters, Emma K. Luhmann, Amy C. Gottschalk, Zhen Xu, Mallory R. Shin, Christopher P. Ptak, Kimberly L. Fiock, Lilliana Radoshevich, Marco M. Hefti

The paper identifies differences in the tau interactome between fetal and Alzheimer disease brains, showing isoform-dependent interactions with 14-3-3 proteins.

eNeuro · Mar 1, 2023Peer-reviewedNeuroscience