Zeru J. Peterson

This study uses machine learning to define the transcriptomic architecture of the human cerebral cortex, revealing a multi-resolution organization and identifying core regions linked to higher cognitive functions.

This study identifies three genes in the 16p11.2 region that replicate sex-specific striatal phenotypes of 16p11.2 hemi-deletion in mice through CRISPR/Cas9-generated 3g del/+ mice.

This study uses spatial transcriptomics to show that sleep deprivation causes region-specific gene expression changes in the brain, with the hippocampus showing the most significant alterations.

This study shows that naltrexone prevents neuroinflammation and epileptogenesis in a mouse model of post-traumatic epilepsy.

This study shows that type I interferon signaling worsens neuropathology and neurologic dysfunction after traumatic brain injury by modulating neuroimmune responses.

This study identifies the lateral septum as a key circuit involved in ketamine-induced social deficits, showing that its hypoactivation contributes to schizophrenia-like behaviors.

The paper identifies five major transcriptional patterns of brain disease risk genes across the adult human brain and highlights species-specific differences in psychiatric and substance abuse-related diseases.