Marco M. Hefti

The paper investigates how selective reduction of KCNA4 in 5HT/glut neurons of the dorsal raphe nucleus contributes to tau pathology and depressive-like behaviors in Alzheimer's disease.

This study identifies QR2 as a reader of H3Q5ser, showing its role in human neuron development through transcriptional and electrophysiological effects.

The paper identifies HSD2 neurons in the human brain and demonstrates their necessity for aldosterone-induced salt intake in mice.

The paper identifies tau pathology in the dorsal raphe nucleus as a potential early indicator of Alzheimer's disease, linked to behavioral changes and neuroinflammation.

This study shows that antiviral drugs fail to prevent neurological deficits in SARS-CoV-2-infected mice, which resemble neurodegenerative diseases due to chronic inflammation.

This study shows that repetitive head impacts in young athletes cause neuronal loss and neuroinflammation before CTE pathology, with specific cellular changes linked to disease progression.

The paper investigates the origins of astrocytic tau aggregates in tauopathies and finds that astrocytes preferentially uptake neuronal 4R tau, which is impaired by inflammation and nutritional stress.

This study identifies the gene expression changes in the human brain following electrical stimulation, revealing non-neuronal cell involvement and a conserved gene signature.

This study shows chronic alcohol exposure increases social avoidance in male mice by enhancing serotonergic inputs to the nucleus accumbens, which inhibits dopamine release and reduces social motivation.

The paper identifies differences in the tau interactome between fetal and Alzheimer disease brains, showing isoform-dependent interactions with 14-3-3 proteins.

This study identifies DNA methylation changes associated with post-operative delirium in neurosurgery patients using genome-wide analysis of blood samples.

This study identifies JADE1 as a novel genetic factor in tauopathy through genome-wide association and functional validation in human and Drosophila models.

This paper evaluates how formalin fixation affects myelin-sensitive MRI metrics like qMT, MWI, and D2O-exchanged ZTE, finding significant increases in qMT and MWI metrics and minimal changes in D2O-exchanged ZTE intensity.