Author

Rajalakshmi Srinivasan

Institute for Stem Cell Biology and Regenerative MedicineORCID 0000-0003-4020-2339Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Systems Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Organism:yeast· 3 Assay:metabolomics· 2 Research Focus:cell signaling & trafficking· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1

Frequent Co-Authors

Sunil LaxmaniD· 3 shared Adhish S. WalvekariD· 2 shared Aswin Sai Narain SeshasayeeiD· 1 shared Gowda Sampreeth Ravi· 1 shared Ritu GuptaiD· 1 shared Swati Shyam Prasad· 1 shared Vandana Sah· 1 shared Vineeth VengayiliD· 1 shared

Activity by Year

2018-2025 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 18 mutual co-author links

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3 shared papersSystems Biology

Sunil LaxmanORCID

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3 papers

Recent·Most cited

Cell BiologybioRxivPreprintJul 1, 2025

Gcn4 regulates phospholipid methylation and SAM dependent methyl allocations between phospholipids and histones during methionine-supplemented growth

Swati Shyam Prasad, Gowda Sampreeth Ravi, Vandana Sah…·Rajalakshmi Srinivasan

This study shows that Gcn4 regulates SAM allocation between phospholipid and histone methylation during methionine-supplemented growth in yeast.

1 citation

yeastmetabolomics

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Systems BiologyPLoS GeneticsPeer-reviewedDec 30, 2020

Genome-scale reconstruction of Gcn4/ATF4 networks driving a growth program

Rajalakshmi Srinivasan, Adhish S. Walvekar, Zeenat Rashida…·Sunil Laxman

The paper shows Gcn4/ATF4 regulates metabolic precursor biosynthesis and translation capacity in yeast growth programs, balancing metabolic supply with translation output.

11 citations

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Systems BiologyMolecular Biology of the CellPeer-reviewedOct 24, 2018

Methionine coordinates a hierarchically organized anabolic program enabling proliferation.

Adhish S. Walvekar, Rajalakshmi Srinivasan, Ritu Gupta, Sunil Laxman

The paper identifies how methionine reprograms yeast metabolism to support proliferation by rewiring key metabolic pathways and co-opting a stress response regulator.

50 citations

yeastmetabolomics

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