Sunil Laxman

This study shows Rad53/Chk2 links mitochondrial function and ROS levels to G2/M cell cycle progression in yeast.

This study analyzes the evolutionary distribution of trehalose breakdown pathways across 4000 genomes, revealing ancestral origins and lineage-specific losses.

The paper identifies Por1 as a mitochondrial protein that represses Snf1/AMP Kinase signaling to limit L-A mycovirus replication in yeast.

The paper identifies Pho4-Pho84 as a conserved mechanism for maintaining intracellular phosphate homeostasis in yeast under phosphate-replete conditions.

The paper shows Scd6 and Edc3 redundantly work with Dhh1 to repress mRNA decay of starvation-induced pathways in yeast.

The paper identifies folate transporters in fungi and plants using genetic and biochemical approaches, showing that OPT family members mediate folate uptake.

The paper shows that cadherin junctions drive metabolic reprogramming in cell clusters, enhancing the pentose phosphate pathway and reducing ROS, with implications for multicellular organization.

This study shows that 3D physical confinement in yeast delays cell cycle progression by restricting bud volume growth, without affecting transcriptional or proteomic responses.

The paper quantifies amino acid dynamics in yeast to identify public and private goods, enabling the design of syntrophic yeast communities.

This study shows that Gcn4 regulates SAM allocation between phospholipid and histone methylation during methionine-supplemented growth in yeast.

The paper identifies Seo1p as a high-affinity transporter for gamma-Glu-met in yeast and fungi, showing its specificity and role in peptide uptake.

The paper shows that mitochondrial morphology in yeast is controlled by the redox state, not mitochondrial activity, and demonstrates reversible control through metabolic changes.

This study identifies diurnal variation in mitochondrial function as a key determinant of time-of-day-dependent exercise capacity in skeletal muscle.

The paper shows cells prioritize restoring amino acids based on demand and biosynthetic cost, with arginine being the highest priority.

The paper identifies Ppg1 as a phosphatase that regulates Far complex assembly to maintain gluconeogenic outputs during glucose depletion in yeast.

The paper shows Gcn4/ATF4 regulates metabolic precursor biosynthesis and translation capacity in yeast growth programs, balancing metabolic supply with translation output.

The paper shows tRNA U34-thiolation regulates phosphate homeostasis, linking carbon and nitrogen metabolism to cell cycle progression by controlling metabolic flux and phosphate availability.

The paper identifies how methionine reprograms yeast metabolism to support proliferation by rewiring key metabolic pathways and co-opting a stress response regulator.

The paper presents a minimal bistability model explaining oscillations between quiescent and proliferative cell states through metabolic resource availability and cell-state communication.