ImmunologybioRxivPreprint
Spatio-temporal regulation of ligand trafficking and TLR9 activation involves PIEZO1 mechanosensing in human plasmacytoid dendritic cells
Shrestha Pattanayak, Deblina Raychaudhuri, Purbita Bandopadhyay…·Dipyaman Ganguly
This study identifies PIEZO1 mechanosensing as a key regulator of ligand-specific TLR9 signaling in human pDCs, showing that CpGA induces IFN production via membrane tension and PIEZO1 activation, while CpGB does not.
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