Molecular BiologyNature CommunicationsPeer-reviewed
Relocation of rDNA repeats for repair is dependent on SUMO-mediated nucleolar release by the Cdc48/p97 segregase
Matías Capella, Imke K. Mandemaker, Lucía Martín Caballero…·Sigurd J Braun
The paper shows that DNA damage triggers rDNA repeat relocation by phosphorylating the CLIP-cohibin complex, leading to SUMOylation and Cdc48/p97-mediated release from the nucleolus in yeast and human cells.