Lucía Martín Caballero

This study shows Lem2, an inner nuclear membrane protein in S. pombe, recruits exosome co-factors to the nuclear periphery to regulate RNA degradation and coordinate transcripts during the mitosis-to-meiosis switch.

The paper shows that DNA damage triggers rDNA repeat relocation by phosphorylating the CLIP-cohibin complex, leading to SUMOylation and Cdc48/p97-mediated release from the nucleolus in yeast and human cells.

The paper shows that subtelomeric sequences in S. pombe are hyper-recombinogenic and have unstable nucleosomes, with Ccq1 protecting them through heterochromatic repression.