Herwig Schuler

This study shows that PARP15's ADP-ribosyltransferase activity is regulated by dimerization, with dimers required for catalytic function and monomers inactive.

This study shows that dimeric SMC motors switch extrusion directionality based on DNA tension, with cohesin being constitutively biased toward one-sided extrusion.

This study evaluates the selectivity of A-966492, a PARP inhibitor, against six PARP family enzymes and finds its selectivity for PARP1 and PARP2 is intermediate between veliparib and niraparib.