Amar Deep

TRIM37 employs peptide motif recognition and substrate-dependent oligomerization to prevent ectopic spindle pole assembly

This study identifies how TRIM37 prevents ectopic spindle pole formation by recognizing peptide motifs in centrobin and undergoing substrate-dependent oligomerization.

A bacterial NLR-related protein senses distinct phage triggers through a single interface

This study identifies a bacterial NLR-related protein that detects phage infection through a conserved interface, triggering programmed cell death to limit viral spread.

Loop extrusion-mediated plasmid DNA cleavage by the bacterial SMC Wadjet complex

This study reveals that the bacterial SMC Wadjet complex uses loop extrusion to specifically recognize and cleave plasmid DNA, establishing loop extrusion as a conserved mechanism across SMC complexes.

A DNA tension-dependent tug-of-war between dimeric SMC motors governs loop extrusion directionality

This study shows that dimeric SMC motors switch extrusion directionality based on DNA tension, with cohesin being constitutively biased toward one-sided extrusion.