Author
National Institutes of HealthORCID 0000-0003-4062-2886Unclaimed ORCID profile · follow to get notified of new preprints
8 papers
Recent·Most cited
Vukasin M. Jovanovic, Narisu Narisu, Lori L. Bonnycastle…·Carlos A. Tristan
This paper describes a scalable method to differentiate human pluripotent stem cells into hypothalamic arcuate neurons, which can model metabolic and reproductive disorders.
Brian N. Lee, Henry J. Taylor, Filippo Cipriani…·D. Leland Taylor
The paper identifies genetic factors influencing iPSC growth rates, finding rare variants in WDR54 and a polygenic background explaining most variance.
Caleb M. Grenko, Henry J. Taylor, Lori L. Bonnycastle…·D. Leland Taylor
This study uses single-cell RNA sequencing to analyze gene expression changes in human pancreatic islets under different glucose conditions over 24 hours, identifying genes and modules associated with time, glucose exposure, and their interaction.
Sarah M. Brotman, Julia S. El-Sayed Moustafa, Li Guan…·Laura J. Scott
The paper identifies additional eQTL signals in adipose tissue and shows they contribute to cardiometabolic traits through gene dosage effects.
Dongxiang Xue, Narisu Narisu, D. Leland Taylor…·Francis S. Collins
This study functionally interrogates 20 T2D-associated genes using isogenic hESC-derived β-like cells, identifying variants and genes linked to insulin production and lipotoxicity sensitivity.
Sanjarbek Hudaiberdiev, D. Leland Taylor, Wei Song…·Francis S. Collins
Henry J. Taylor, Yu-Han Hung, Narisu Narisu…·D. Leland Taylor
This paper identifies miRNAs associated with type 2 diabetes and glycemic traits through genetic analysis of miRNA expression in human pancreatic islets.
Julia S. El-Sayed Moustafa, Anne Jackson, Sarah M. Brotman…·Kerrin S. Small
The paper examines the association between adipose tissue ACE2 expression and cardio-metabolic risk factors, finding lower ACE2 levels linked to T2D, obesity, and inflammation-related cell type changes.