Yu-Han Hung

Generation of a biliary tract cancer cell line atlas reveals molecular subtypes and therapeutic targets

This study creates a biliary tract cancer cell line atlas using multi-omics data to identify molecular subtypes and therapeutic targets.

Integrative genome-scale analyses reveal post-transcriptional signatures of early human smallintestinal development in a directed differentiation organoid model

The paper identifies post-transcriptional regulators in early human small intestinal development using multi-omic analyses and presents a web tool for exploring miRNA regulation.

Human pancreatic islet microRNAs implicated in diabetes and related traits by large-scale genetic analysis

This paper identifies miRNAs associated with type 2 diabetes and glycemic traits through genetic analysis of miRNA expression in human pancreatic islets.

Super-enhancer signature reveals key mechanisms associated with resistance to non-alcoholicsteatohepatitis in humans with obesity

The paper identifies distinct enhancer signatures in NASH-prone and NASH-resistant human obesity patients, revealing key genes and pathways associated with resistance.

Chromatin regulatory dynamics of early human small intestinal development using a directed differentiation model

The paper uses ChRO-seq to study chromatin dynamics during human small intestinal development, identifying enhancer activity and transcription patterns at HOX gene loci.

Single Cell Analysis Reveals Multi-faceted miR-375 Regulation of the Intestinal Crypt

This study identifies miR-375 as a key regulator of intestinal crypt homeostasis, showing its role in stem cell proliferation, tuft cell abundance, and resistance to infection and cancer.