Samudrala Gourinath

This study characterizes the recombinant Rtt109 histone acetyltransferase from Candida albicans, identifies its functional requirements, and screens for potential inhibitors with clinical implications.

This study functionally characterizes LmME2, a cytosolic malic enzyme in Leishmania major, showing its role in pyridine nucleotide homeostasis, redox balance, and virulence.

This study identifies EhRho2 as the most specific and high-affinity target of EhFP10, revealing a selective GEF-GTPase interaction in E. histolytica with potential therapeutic implications.

This study identifies EhPHDK as a critical kinase for Entamoeba histolytica survival, phagocytosis, and cytoskeletal dynamics, with potential as a therapeutic target.

This study identifies CaFun30 as a potential antifungal target by screening a small molecule library and validating F1853-0039 as a lead inhibitor against C. albicans.

The paper determines cryo-EM structures of E. histolytica ribosomes, revealing unique features like an RNA triple helix and co-evolved rRNA expansion segments.

This study identifies nPIST as a novel actin binding protein in Purkinje cells, showing it interacts with GluRδ2 and stabilizes actin filaments through multiple binding regions.

The paper identifies a WH2 domain in the actin cross-linking domain of VgrG-1 toxin that mediates actin binding and cytoskeleton disruption in host cells.