Rachel Brody

This study shows GM-CSF reduces intestinal inflammation in Crohn's disease by modulating myeloid cell signaling and ILC-like transcriptional states.

The paper identifies AP-1 family transcription factors as critical regulators of beta cell maturation by analyzing epigenomic and transcriptomic profiles of human insulinomas.

This study shows ATM regulates metabolic stress in SCLC by affecting ATF4 and MYC, leading to ferroptotic cell death and revealing a new therapeutic target.

The paper shows lactating serum has anti-cancer effects targeting PAPP-A-expressing cells and identifies CRF as a key mediator of this effect through mitochondrial inhibition.

The paper assesses low-biomass microbiome detection in tissues using long-read sequencing, finding that genuine microbiome signals are limited to tissues with natural microbial exposure.

The paper constructs a spatial transcriptomic atlas of human skin, identifying 45 cell types across 15 sites and revealing neighborhood disruptions in disease.

The paper identifies TREM2-expressing macrophages as predictors of response to PD-1 blockade in HCC patients using clinical and spatial transcriptomic data.

MARQO pipeline automates single-cell analysis of multiplex immunostained tissue slides, showing improved accuracy over manual methods in cancer studies.

The paper benchmarks deconvolution tools for spatial transcriptomic data and introduces a novel pipeline to analyze tissue microenvironment dynamics.

This paper uses single-cell RNA-sequencing to analyze the tumor microenvironment in pleural mesothelioma, identifying gene programs, fetal-like endothelial cells, and a new therapeutic target.

This paper develops a deep-learning model to assess kidney biopsy images, predicting graft loss and guiding organ utilization by improving upon traditional scoring methods.